Mutant/mutation
The mutant lacks expression of APE1 and expresses GFP

Protein (function)
The protein is an ExoIII family endonucleases (proteins involved in organellar base excision repair (BER pathway). The P. falciparum nuclear genome encodes two class II AP  endonucleases– an endonuclease IV (EndoIV/Nfo) family protein (PfApn1) and an exonuclease III (ExoIII) homolog (PfApe1) The parasite ExoIII family endonuclease, PfApe1,  has a strong mitochondrial targeting prediction.

Phenotype
Prolonged prepatent period after infecting mice intravenously with sporozoites (prolonged with 2 days).
In cultured heaptocytes Ape1(-) parasites develop into EEFs and egress from hepatocytes normally. Normal merosome formation and segregation of merozoites. Evidence is presented the merozoites from merosomes have decreased infectivity.

Additional information
Evidence is presented that: PfApe1 localized in the mitochondrion and exhibited AP-site cleavage, 3′-5′ exonuclease, 3′-phosphatase, nucleotide incision repair (NIR) and RNA cleavage activities

Other mutants