RMgmDB - Rodent Malaria genetically modified Parasites
Search for genetically modified parasite lines by:
Search database by RMgm ID
6 results for: crt
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RMgm-610Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_1219500; Gene model (P.falciparum): PF3D7_0709000; Gene product: chloroquine resistance transporter (CRT)
Details mutation: crt of P. berghei replaced by the (chlorquine-sensitive, HB3) P. falciparum crt gene (MAL7P1.27)
Phenotype Asexual bloodstage; Gametocyte/Gamete; Oocyst;
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RMgm-611Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_1219500; Gene model (P.falciparum): PF3D7_0709000; Gene product: chloroquine resistance transporter (CRT)
Details mutation: crt of P. berghei replaced by the (chloroquine-resistant, 7G8) P. falciparum crt gene (MAL7P1.27)
Phenotype Asexual bloodstage; Gametocyte/Gamete; Oocyst;
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RMgm-969Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_1109400; Gene model (P.falciparum): PF3D7_0509800; Gene product: phosphatidylinositol 4-kinase (PI4K; PI(4)K)
Details mutation: PbPI(4)K(His1477Tyr) (equivalent to His1484Tyr in PfPI(4)K)
Transgene Transgene not Plasmodium: A fusion of GFP (gfp-mu3) and Luciferase Firefly (LucIAV)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Liver stage;
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RMgm-5041Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_1219500; Gene model (P.falciparum): PF3D7_0709000; Gene product: chloroquine resistance transporter (CRT)
Details mutation: a mutated CRT with amino acid change N331I
Phenotype Asexual bloodstage;
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RMgm-5517Malaria parasite P. yoelii Genotype Mutated Gene model (rodent): PY17X_1241800; Gene model (P.falciparum): PF3D7_0523800; Gene product: food vacuole resident transporter 1 (FVRT1, PyDMT1 (Divalent metal transporter 1))
Details mutation: The 5' UTR of the dmt1 gene is truncated.
Phenotype Asexual bloodstage;
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RMgm-5544Malaria parasite P. yoelii Genotype Mutated Gene model (rodent): PY17X_0210200; Gene model (P.falciparum): PF3D7_0104300; Gene product: ubiquitin carboxyl-terminal hydrolase 1, putative (UBP1)
Details mutation: UBP1 mutated - two mutated amino acids (I1560N and P2874T)
Phenotype Asexual bloodstage;